![]() ![]() ![]() It is indispensable for proper carbohydrate metabolism and in ensuring systemic capacity to withstand events of stress such as infection and trauma. The primary site of action of aldosterone is at the renal distal convoluted tubules and the cortical collecting ducts, where it promotes reabsorption of the crucial 2% of sodium to be regained from the renal filtrate.Ĭortisol, the principal GC in humans and most mammalian primates ( 1) is quantitatively the main secretory product of the adrenal cortex. It is the most potent steroid affecting active transport of sodium ions across membranes and thus in maintaining electrolyte balance. In: Genetic and Molecular Biological Aspects of Endocrine Disease Balliere Tindall: London, 1995, pp: 526.)Īldosterone is the end product of the MC pathway.
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